Andhra University Research Team Identifies Mechanism Impacting Covid Vaccine Efficacy

A research team from Andhra University has pinpointed a molecular process that could have implications for the efficacy of Covid-19 vaccines, suggesting potential challenges in long-term protection. Led by Dr. Ravikiran S Yedidi, the researchers made this groundbreaking discovery at TCABS-E Laboratories, located at Andhra University. Their findings, which were recently published in an Elsevier journal on November 19, 2025, shed light on how the Coronavirus might evade antibodies generated by Covid-19 vaccinations. By studying the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, the team has uncovered crucial insights into how the virus interacts with human cells through the ACE2 receptor.